Chelator-conjugated polymeric nanoparticles for imaging applications and theranostics


Torrubiano Balcells, Marta


There is a growing incidence of neurodegenerative diseases due to the aging of population. One of the most common causes of dementia in the elderly is Alzheimer disease (AD). Oxidative stress and mitochondrial dysfunctions are supposed to be the main causes of AD. There is an urgent need for an effective treatment and early diagnosis of this disease. Therefore, nanomedicine has become a potential strategy to improve diagnosis with the development of imaging tools and the treatment for AD. This project is aimed at studying the potential of polymeric nanoparticles (NP) prepared from oil-in-water nano-emulsion templates to prepare multifunctional materials as promising nanotheranostics. Chelator-conjugated polymeric nanoparticles with a mitochondrial targeting ligand were synthesized and studied for both, imaging, and therapy medical applications. Rosmarinic Acid an antioxidative drug was successfully encapsulated in these multifunctionalized NPs. Additionally, the encapsulation of this NPs in hydrogels was studied for future applications.



Fornaguera i Puigvert, Cristina
Grijalvo, Santiago; Rodríguez, Carlos


IQS SE - Undergraduate Program in Chemical Engineering