Daphnia magna exposure to β-blockers and neuroactive pharmaceuticals


Goyenechea Cunillera, Júlia  


The presence of drugs in surface waters has been a topic of growing interest in the last years. Its global presence in aquatic systems is now recognized by the community scientific risk and the risk they pose to the environment poses a serious problem. The interest in biological models are increasing daily to investigate the effect of deregulation neurotransmitters, caused by pharmaceuticals, on the structure and function of central nervous system, thus understanding the neurotoxic effect of these contaminants. The Daphnia magna represents an excellent aquatic model for these environmental studies, due to their similarities to vertebrates in various neurotransmitters and genomes related, as well as for its wide application in ecotoxicological studies.
In the present work, the relevance of Daphnia magna in ecotoxicology studies is  reviewed classic and current, especially for five drugs: the β-blockers  propranolol and metoprolol, isoprenaline (antagonist propranolol), antiepileptic carbamazepine and sedative diazepam. Analytical methods associated with the analysis of neurotransmitters and related metabolites as well evaluate, in terms of sensitivity, repeatability, reproducibility and overall robustness, determining the optimal conditions for the analysis of the selected compounds. Finally, the relationships between the metabolic pathways involved are established to have one reliable tool for understanding the effects of neuroactive compounds on the profile of neurotransmitters of Daphnia magna.



Gómez Canela, Cristian


IQS SE - Grau en Química