Diseño, Síntesis y caracterización de nuevas moléculas moduladoras del receptor nuclear PPAR-γ

Author

Palomino Gonzalez, Dario Castro

Abstract

Cancer is one of the most studied and deadly disease. Many types of treatments have been designed to mitigate, alleviate, or cure the effects of cancer, some of them biologicals and other small molecules, which have helped to increase the life expectancy of patients with this disease. Despite this, the complexity of cancer makes current treatments partially effective or the disease develop resistance to them, which means that the unmet medical need for new cancer treatments remains very high.
In this work, we have focused on the fundamental role that PPAR-γ plays in immune cells and in the immunosuppressive response as a consequence the activation of the receptor in cancer disease. Blocking this response with specific antagonists could activate the immune system and open the door to a new effective cancer treatment.
Inspired by the crystallized structure of PPAR-γ covalent antagonist GW-9662, more than 30 new compounds have been designed, synthesized, and characterized. Some of them show a high affinity against the receptor.

Director

Puig de la Bellacasa Cazorla, Raimon
Roberts, Richard

Degree

IQS SE - Undergraduate Program in Pharmacy

Date

2022-09-05