Diseño y Aproximación Sintética de una Etiqueta Bioconjugable basada en Trifluoroboratos Amónicos para Imagen PET con Flúor 18


Collera Gratacòs, Maria 


Positron emission tomography (PET) is a highly sensitive and noninvasive molecular imaging technology that helps to better understand the biology of diseases. This technique is based on the use of radiomolecules -radiotracers- for in vivo imaging of biological and biochemical processes. There are several types of radionuclides used in PET with different half-lives. In the present work the 18F isotope has been the one of choice due to its nuclear properties. The design and incorporation of the 18F atom in some radiotracers is an issue not entirely solved by chemical reactions of C-18F bond formation and, therefore, new tools for the synthesis of 19F-radiotracers are needed.
To contribute to this goal, in this Final Degree Project, we have carried out the design and first synthetic attempts of a new molecule that includes an ammonium trifluoroborate fragment (AMBF3), an advantageous functional group for the introduction of 18F by halogen exchange and that also contains an activated cyclooctyne-type structure to be employed in metal-free click-type bioconjugation reactions. The combination of these two particularities is considered particularly suitable in this PET context and has not been explored so far.



Cuenca González, Ana Belén


IQS SE - Undergraduate Program in Pharmacy