Glycolipids synthesis as vectors to antigen presenting cells for the design of mRNA vaccines as a new treatment for lung cancer, based on oligosaccharide modified poly (beta aminoester) nanoparticles

Author

Salas i Santana, Marc

Abstract

Cancer is a well-known problem worldwide and, although important advances have been made, it seems that we are still far from eradicating this disease. Currently, immunotherapies are becoming the standard treatment for many types of tumors, although their efficacy is still limited, specifically for cancers affecting internal organs. With the emergence of new technologies, nanosystems, especially nanoparticles, have gained ground in the healthcare sector. One of their uses is the application of therapeutic vaccines, but today these new treatments have certain limitations.
The vaccine to be developed aims to present an mRNA coding for tumor-associated antigens (TAAs) selectively to dendritic cells and activate the immune system. The objective of this project is the synthesis of molecules, as vectorizing agents of the nanoparticle, to increase the affinity of the nanoparticle for dendritic cell receptors. Since dendritic cells have many Ctype lectin receptors, a rational targeting moiety would be an oligosaccharide. Of the selected molecules, we were able to functionalize the galactose unit of the disaccharide fucα1-2gal and to derivatize fucose α.

Director

Fornaguera Puigvert, Cristina
Faijes Simona, Magda

Degree

IQS SE - Undergraduate Program in Chemistry

Date

2022-06-18