Liofilización de concentrados para perfusión preparados a partir de complejos ciclodextrinados. Fármacos antigúngicos sistémicos


Bové Cemeli, Marc


This end-of-degree project is focused on the study of the development of lyophilized voriconazole formulations for its subsequent administration. Voriconazole is a second generation triazole and as such offers a broader spectrum of activity than its predecessors. It can be administered either orally or intravenously. It is especially indicated in the treatment of invasive aspergillosis, as well as in resistant Candida infection. The main challenge to address during this development has been the low aqueous solubility of voriconazole and its lack of stability in water, which, together with its semi-polar nature, determine the feasibility of obtaining a stable intravenous formulation.
For this reason, the main objectives of this work have been focused on obtaining high-yield voriconazole-cyclodextrin inclusion complexes and in a subsequent lyophilization process, thus ensuring the development of the aforementioned formulation.



Artalejo Ortega, Beatriz
Balfagón Costa, Alberto


IQS SE - Undergraduate Program in Pharmacy