Author Rivero Farré, Albert |
Abstract In recent years, the number of infectious diseases that do not respond to antibiotic treatments has increased to become a major threat to public health systems worldwide. Several of these diseases are due to multi-resistant bacteria for which there is no effective treatment. As a result of this problem, silver nanoparticles have taken center stage due to their antibacterial properties, which are based on a combination of mechanisms of action other than the targets that antibiotics target. Knowing and controlling the physicochemical parameters of nanoparticles, as well as being able to modulate their surface is crucial to regulate their biological response, toxicity and stability.In this work, a state of the art will be carried out in order to identify which are the mechanisms of action of silver nanoparticles and what key parameters need to be controlled to maximize their bactericidal effect. Experimentally, starting from a formulation of silver nanoparticles based on the Tollens synthesis, it is intended to study by robust techniques whether the synthetic method allows the generation of reproducible silver nanoparticles with the appropriate properties to be able to carry out in vitro studies with bacteria. Finally, it is intended to coat the formulated nanoparticles with an albumin biocrown, which raises questions about how it will affect colloidal stability, what effect it will have on the observed toxicity and, ultimately, how the corona modulates the interaction between the nanoparticle and the bacteria. |
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Director Texidó Bartés, Robert |
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Degree IQS SE - Undergraduate Program in Chemistry |
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Date 2020-09-08
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