Design and synthesis of multitarget tyrosine kinase inhibitors for the treatment of pancreatic ductal adenocarcinoma

Author

Torres Urtizberea, Endika 

Abstract

Among all the different cancers, pancreatic cancer is considered to have one of the lowest survivability rates. Currently, among the only five approved small drugs in the U.S. by the FDA for the treatment of this cancer two of them target growth factor receptors (GFR), that’s why, the inhibition of these kind of proteins has become of interest. Furthermore, due to drug resistance linked to cross talks between these, the necessity of selective multiple growth factor inhibitors has grown among the medicinal scientists.
Using computer aided drug design approach and deep learning technics, different activity prediction models have been developed against important GFR in pancreatic cancer. These models are applied on the pyrido[2,3-d]pyrimidine scaffold due to its versatility. At the same time, different synthetic methodologies have been explored for obtaining the predicted compounds.

Director

Estrada Tejedor, Roger
Puig de la Bellacasa Cazorla, Raimon

Degree

IQS SE - Máster en Química Farmacéutica

Date

2019-12-10