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Author Font-Quer i Roset, Núria |
Abstract Nanomedicine is a field of nanotechnology that is gaining interest as a drug to treat diseases, such as genetics. This group of diseases can be treated with gene therapy with viral or non-viral vectors. As non-viral vectors we can find polymers, specifically Poly (β-amino esters) (PBAE). PBAEs are bio-compatible, biodegradable polymers that show promise as non-viral vectors since they have low cytotoxicity, could be a valid substitute for viral vectors but have low stability compared to viral vectors. PBAEs are usually formulated in liquids, it is believed that solid formulations are more stable than liquid ones and that is why the objective of this work is to propose a lyophilization plan for PBAEs with DNA. Given the current pandemic, planning will be bibliographic and will aim to check if the solid formulation of this product will be stable. One of the challenges to commercialize nanoparticles is the lack of legal framework, sterility and lack of characterization, which are points that have been taken into account when the lyophilization plan has been proposed. |
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Director Fornaguera Puigvert, Cristina |
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Degree IQS SE - Undergraduate Program in Pharmacy |
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Date 2020-09-07
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