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Author Alkayal, Housam |
Abstract Different specific reaction conditions of the aza-Michael reaction are explored, which can be used in combination with flow chemistry to improve industrial API production. This project involves the use of different Michael acceptors and aza-type donors, to expand the applicability of the method in collaboration with an industrial company. For this, the work includes the use of 4-vinylpyridine and different amines, both in batch and in flux, to make a direct comparison between them. Furthermore, the results are compared with those obtained with 2-vinylpyridine, also in batches and in flow. It is observed that the behavior of the mixture of 4-vinylididine with the aqueous solution of an amine salt provides a single phase, unlike 2-vinylpyridine, which gives two, this fact may be due to the formation of micelles. Previous work with 2-vinylpyridine has shown that increasing the temperature improves its performance and selectivity. However, for 4-vinylpyridine, the increase in temperature causes the yields to decrease. The best conversion, yield and selectivity results are obtained by increasing the residence time in the flow reactor. |
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Director Sempere Cebriàn, Julià |
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Degree IQS SE - Master’s Degree in Pharmaceutical Chemistry |
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Date 2021-09-21 |
