Cytostatic drugs as a potential risk in surface waters


Gibert Amat, Marta


Cancer causes many deaths each year around the world. It is basically treated with cytostatics. These components have very different physicochemical properties, for this reason they are eliminated by different routes. But after they are eliminated, they end up in wastewater, which the treatment plants are not able to eliminate completely. Therefore, they are found in surface waters. LC-MS / MS analysis has been carried out. In a water sample from the Besòs treatment plant, the following drug concentrations (ng / mL) were found in decreasing order: prednisone (44.85), mycophenolic acid (36.87), bicalutamide (5.97), cyclophosphamide (1.87), ifosfamide (1.42), megestrol and cyproterone (0.3), and lastly, gemcitabine (0.51). Due to the state of sanitary alarm, only one sample could be analyzed, and the method could not be optimized for all the components to be analyzed. In conclusion, it has been seen that there is a presence of these compounds in surface waters, and that, therefore, it can affect our health.
Keywords: cancer, cytostatics, chromatography, wastewater, surface water, LC-MS / MS.



Gómez Canela, Cristian


IQS SE - Undergraduate Program in Pharmacy