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Autor/a
Lujan Pallarès, Enric
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Abstract
Antibiotic resistance is a global public health problem that threatens the ability to treat infectious diseases. This is defined as a natural process by which bacteria area able to develop defenses against the drugs used in their treatment. The abuse and misuse of antibiotics have accelerated the appearance and spread of resistant bacterial strains worldwide. However, the approval of new antibiotics is severely limited by strict regulation.
In the present work, an optimal substrate is proposed for the development of an amperometric HClO sensor. Standard determinations have been made using substrates based on a TiO2 nanotubes array and substrates with RuO2, an oxide known for its catalytic effect on the chlorine evolution reaction. All substrates under study have been compared with the platinum electrode.
It is also proposed to use electrochemically generated HClO from a saline solution as a new strategy to treat bacteria that cause infections which are hard to cure. In order to do so, the antibacterial activity of HClO has been tested at three levels of complexity: planktonic bacteria, bacteria in the biofilm mode of growth on silicone discs and bacteria in the biofilm mode of growth on the inner walls of silicone catheters.
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