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Author
Alís Colominas, Anna
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Abstract
Synthetic catinones, considered as new psychoactive substances (NSPs), are defined as substances of abuse not legally controlled by the 1961 Single Convention on Narcotic Drugs or the 1971 Convention on Psychotropic Substances.
The appearance of these compounds has been on the rise in recent decades and poses a high risk to public health. They are composed of a structure analogous to illicit drugs, such as amphetamines, cocaine or or MDMA, also known as ecstasy. This means that they have a high potential for addiction and psychostimulant effects, followed by very severe adverse effects similar to illicit drugs. Research into the effects and toxicology of synthetic catinones is still ongoing.
With the emergence of NSP, the United Nations Office on Drugs and Crime (UNODOC) has begun conducting international monitoring where
all the data, specific information, trends, toxicology ... about them and try to regulate the illegal synthesis of synthetic catinones thus protecting health public and human well-beingIn this work we will synthesize a type of synthetic catinone called: 4-chloro-alpha-pyrrolidinevalerophenone (4-Cl-α-PVP).
A crystallization of this product with tartaric acid resulting in a diastereomeric salt will then be carried out and it will be identified and characterized for the purpose of to be able to carry out a subsequent study on the pharmacological potential and toxicology of each of the enantiomers of the compound.
Catinone synthesis was performed following the procedures described by Meltzer et al. (2006) and the tartrates of L and D tartaric acids have crystallized by observing the separation potential of enantiomers by NMR.
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