Evaluación de las bases matriciales (HPMC) en comprimidos de Clorhidrato de Metformina


Rovirosa Serra, Albert


By means of conventional oral drugs, a rapid release of active principle is achieved but, in turn, they have limitations such as the appearance of fluctuations in drug concentrations in the blood. In addition, it is necessary to increase the frequency of taking the medication, to maintain its effectiveness. This fact can negatively impact in patient adherence. On the contrary, the modified release dosage forms (MRDF) allow the release and vectorization of the active principle to be modulated. One type of MRDF is the extended-release dosage forms made of hydrophilic matrices of a polymer called hydroxypropylmetylcellulose (HPMC). The main objective of this work is to study and evaluate the behavior of the hydrophilic matrices of hydroxypropylmetylcellulose (HPMC), using metformin hydrochloride as a tracer To carry out the study, 4 different formulations were proposed, modifying three different variables: proportions of HPMC 2910, the water content and the hardness of the tablets.



Artalejo Ortega, Beatriz
Balfagón Costa, Alberto


IQS SE - Undergraduate Program in Pharmacy