Exosomas cargados con Doxorrubicina: un nuevo sistema de liberación controlada para la terapia del melanoma


Cantón Fumanal, Emma


Melanoma is one of the most aggressive forms of skin cancer, with a high incidence and mortality rate, and with very few therapeutic options. For this reason, a lot of research is focusing on developing more effective, safe and survival-enhancing therapies, many of them based on the application of nanotechnology, consisting of the use of nanometric systems as carriers of active principles. However, traditional nanosystems based on synthetic vectors have drawbacks in terms of safety and activation of the immune system. Consequently, exosomes have recently aroused great interest as new drug delivery systems due to their intrinsic capacity for cellular communication, their nanometric size that avoids being detected by the immune system, their natural origin and the tendency or selectivity to go directly to the cells of their own lineage. For this reason, the main objective of this project, taking advantage of these promising properties of exosomes, is to test different methods of encapsulation and purification of exosomes with an antineoplastic drug as well as the subsequent characterization. Finally, the results obtained in vitro have shown to be promising and valid results to continue working and to become a good system and alternative for therapies against melanoma.



Fornaguera i Puigvert, Cristina


IQS SE - Undergraduate Program in Pharmacy