Multi-Component Chemistry as a Source of Innovative Broad Spectrum Antiviral Agents


Parra Tejedor, Carles


The influenza virus is a biological agent capable of generating terrible health crises. To fight against the effects of the influenza-derived flu, some targets across the viral structure have been studied. Historically, the inhibitors targeting the viral NA surface membrane protein were the most used and recognized. However, other targets are emerging lately as better and more suitable biological targets, such as the RdRp and the interaction between its subunits.
The research group of Prof. Massari within the “Università degli Studi di Perugia” has been studying the interaction between viral RdRp subunits PA and PB1 as a potential therapeutic target. Almost ten years ago they started researching about it and they have ended up with some biologically active scaffolds, like triazolopyrimidines (TZPs), among others.
Historically, the research group has synthesized these TZPs mainly through conventional two-component reactions. However, a new approach suggests that the mentioned scaffolds could be obtained starting from a multi-component reaction (MCR), saving time, resources and op-timizing the process overall.
Thus, in the present work different structures derived from the TZP scaffold are proposed and synthesized through MCRs with the aim of inhibiting the PA-PB1 interaction and, hopefully, preventing the replication of the virus.



Cuenca González, Ana Belén
Massari, Serena


IQS SE - Master’s Degree in Pharmaceutical Chemistry