Síntesis y caracterización de un posible metabolito y estudio del metabolismo biomimético de dos candidatos a fármaco para tratar cáncer de pulmón

Author

Fernández Romero, Odile

Abstract

The development of drugs for the treatment of cancer continues to be a scientific frontier. One of the strategies proposed among the different lines of research against cancer is inhibition of kinases. This is a group of enzymes that play a fundamental role in the modulation of cell growth signals and whose dysfunction can lead to uncontrolled proliferation of tumor cells. The development of this type of pharmacological therapy would allow a more selective treatment than conventional ones and would be therefore less aggressive for the patient.
After years of research, it is known that some pyrido[2,3-d]pyrimidine structures could be good drug candidates. Pyrido[2,3-d]pyrimidines compete with ATP for the kinase binding center, thus inhibiting the activity of these enzymes. This project proposes a route to synthesize a metabolite of a possible drug whose structure is determined by the results of previous studies.
On the other hand, the oxidation of a drug with a pyrido[2,3-d]pyrimidinic structure is studied. The differences between the product obtained using only an oxidant and adding a biomimetic catalyst are described.

Director

Borrell Bilbao, José Ignacio
Puig de la Bellacasa Cazorla, Raimon

Degree

IQS SE - Undergraduate Program in Chemistry

Date

2021-06-20