Presence and toxicity of pharmaceuticals used to treat SARS-CoV-2 in aquatic environment from Catalonia


Rodríguez Ortiz, Reinerio


COVID-19 disease caused by SARS-CoV-2 virus was declared global pandemic in March 2020 causing millions of deaths. An evident tendency of global pharmaceutical consumption due to COVID-19 pandemic should be seen worldwide and this increase might suppose an environmental threat. These pharmaceuticals administration can be at home or in hospitals, where then are excreted via feces and urine after their consumption and finally reach aquatic systems such as rivers and oceans. The Wastewater Treatment Plants (WWTPs) are the machinery in charge for the residue elimination, however in the case of pharmaceuticals, they are unable to remove them completely. For this reason, analytical techniques such as liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) have become prominent to identify and quantify pharmaceutical residues in aquatic matrices. In view of the scarce data on the occurrence of pharmaceuticals used as COVID-19 treatment, the aim of the present study was to evaluate the presence of these class of pharmaceuticals in river water which are dexamethasone, prednisone, ciprofloxacin, levofloxacin, remdesivir, ritonavir, lopinavir, acetaminophen, hydroxychloroquine, chloroquine and cloperastine, their toxicity in the aquatic environment using Daphnia magna and to realize an exhaustive risk assessment in different points of the Llobregat and Besòs rivers.



Gómez-Canela, Cristian


IQS SE - IQS SE - Master’s Degree in Pharmaceutical Chemistry