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Author
Tintoré Vidal, Silvia
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Abstract
In 2023 a new legislation will ban the use of animals in the cosmetic industry worldwide. This fact leads to today’s society to look for new alternatives providing safety and efficacy to cosmetic and active ingredients.
Synthetic artificial membranes offer a simple and reproducible alternative to human and animal skins in the evaluation of new cosmetics or transdermal drugs for some of its advantages, as control of the membrane thickness, hydrophilicity, non-toxicity, biodegradability, and reproducibility along with ethical concerns.
In this work, three-layered chitosan membranes have been prepared in an attempt to approach human skin. As drug permeation is one of the most important pathways for topical drug evaluation, chitosan membranes were activated to form pore channels between layers and hence, to mimic skin pores.
Two different methodologies of activated membranes have been studied been the mechanical method able to enhance permeability through membranes by controlling the distribution and quantity of pores on the membrane.
Once the optimal method for the obtention of activated membranes has been implemented, It was studied the permeability of diclofenac and ibuprofen using Franz Diffusion cell.
Due to Covid-19 circumstances, it has not been able to quantify drug permeation and to finish this part of the project. However, several methodologies have been proposed for future experiences to continue studying in a completely way chitosan membrane permeability in order to become a good alternative to human skin.
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