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Author
Domínguez García, Pol
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Abstract
The abuse of drugs such as methamphetamine has grown in the last ten years and is considered a serious problem for society. Not only are drug-related health problems observed, but also economic and social problems are derived as a consequence of this abuse. One of these problems is the alteration of the monoaminergic system that some drugs can cause, affecting neurotransmitters in the brain.
Animal models such as the zebrafish (Danio rerio) are being increasingly used for neurobehavioral studies. They are small, cheap, and relatively easy to breed and maintain. They also share the same monoaminergic system as humans. Behavioral studies are a great tool to see changes in the locomotor system and certain trends when fish are exposed to a drug and LC-MS / MS analytical technology allows to quantify the profile of the different neurochemicals of the monoaminergic system directly from the brain of the fish. zebra fish. Beyond that, the same methamphetamine can also be quantified.
In this work, a robust method is developed for neurotoxicity studies using zebrafish as a toxicological model.
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