Synthesis and biological testing of new compounds potentially active in haematological cancers

Author

Gorjón de Pablo, Gema

Of all types of cancers, leukemias are the dysplasias with the highest incidence and mortality in children. On the other hand, diffuse large B-cell lymphoma is one of the most common lymphomas in the adult population and one of the most aggressive, especially the ABC subtype. The treatment of these diseases is based mainly on chemotherapy, immunotherapy, targeted therapy, and in some cases, bone marrow transplantation. The discovery of new, more specific therapies that allow treating this type of hematological cancer, avoiding possible relapses and/or resistance to current treatments, is one of the most sought-after objectives in the treatment of leukemia and lymphoma.
To this end, in this work candidates with a pyrido [2,3-d] pyrimidin-7 (8H) -wave structure potentially active against LUBAC have been synthesized. This drug target is related to various immunological, inflammatory, and cell survival processes that promote oncogenesis and angiogenesis.

Director

Estrada Tejedor, Roger
Montagut Pérez, Ana Maria

Degree

IQS SE - Master’s Degree in Chemical Engineering

Date

2021-06-21