Understanding the albumin binding capacity to metals and its role in disease


González Torres, Jordi

Albumin is the main circulating protein found in plasma and plays a fundamental role in the distribution of endogenous and exogenous compounds, including ions such as Cobalt, Cop-per and Nickel. Previous studies have shown that alterations in the Albumin binding capacity could be involved in different pathologies. In particular, deficiency in Albumin metal ion binding capacity may contribute to Alzheimer pathogenesis. Additionally, it could potentially become an indicator biomarker of liver dysfunction. The purpose of this study was to set-up and opti-mize a spectrophotometric method to indirectly determine the content of Copper bound to albumin in biological fluids, and evaluate the effect of the metal-binding properties of Albumin. To do that, in vitro models for Albumin glycation and oxidation, and recombinant isoforms of human serum Albumin were used.



Planas Sauter, Antoni
Alcaraz, Estefanía


IQS SE - Master’s Degree in Bioengineering