Aplicación de los complejos ciclodextrinados en la vehiculización de fármacos sistémicos


Bosque Guarner, Miguel


The work carried out during the final degree project is framed in the development of the application of cyclodextrin complexes in the delivery of systemic drugs. Specifically, complexes with sulfobutyl ether have been used. Cyclodextrin as a vehicle for a hydrophobic drug such as voriconazole. Cyclodextrins are characterized by acting as excipients that improve the physical-chemical properties of the active ingredient such as stability, solubility and bioavailability of the active ingredient. Voriconazole is an antifungal used to treat infections systemic fungal. It belongs to the group of antifungals second- generation triazoles that have more potency and activity against resistant fungi than the first generation.
That is, second-generation antifungals, such as voriconazole, they need a lower dose to achieve the same answer.
The main objective of this work is to obtain a voriconazole microencapsulation with cyclodextrin to solubilize voriconazole and that it can be administered systemically without causing rejection. Therefore, firstly, the complex of inclusion and later, once achieved, we try to optimize the process.



Artalejo Ortega, Beatriz
Balfagón Costa, Alberto


IQS SE - Undergraduate Program in Pharmacy