Glycolipids production using metabolic engineering strategies


Zarza Bardet, Miguel


The a-galactosylceramide it’s a synthetically obtained glycolipid which can be used in fields related to medicine due to its strong immunostimulating and antitumor activity. Based on this, the general idea of the project is to evaluate the organism pichia pastoris as a possible alternative to Saccharomyces cerevisiae as a biological platform on which to carry out different metabolic engineering strategies in order to increase the production of α-galactosylceramide. This project is a purely bibliographic work in which it is intended to compare the metabolic routes for the synthesis of sphingolipids corresponding to each of the two organisms and to determine what they will mean to be carried out to increase the production of α-galactosylceramide, trying to foresee what problems it could lead to the modification of certain routes in the viability of both organisms. On the other hand, the project also presents the possible applications both the industrial and biomedical uses of ceramide and its derivatives.



Faijes Simona, Magda


IQS SE - Undergraduate Program in Biotechnology