Calvet Carnicé, Arnau
Antiphospholipid syndrome (APS) is a multisystem disorder characterized by arterial and/or venous thrombosis or recurrent fetal loss accompanied by persistently
positive for antiphospholipid antibodies (APL). APS is the most common cause of acquired thrombophilia; however, significant controversy remains over its pathogenesis and not much is known about its mechanism of action.
On the other hand, extracellular vesicles (EVs) are submicron particles that are released by all cells. For the most part, miRNAs have been found to be conserved within these particles. These are small RNAs involved in the pre-activation of biological pathways and have been found to be essential in the pathogenesis of diseases. Although most of this research has focused on cancer, there are no studies linking miRNAs encapsulated in EVs with APS. However, it has been shown that elevated levels of EVs reflect a general state of cellular activation. Therefore, our hypothesis is that microRNAs in EVs could be key to understanding APS pathology and could be a new source to find gene and selective therapies for these patients.
For the first time, in this project it is proposed to carry out a miRNA-seq study to discover the miRNAs that are found within the EVs from the sera of patients with APS and find out what role they have in the disease.