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Author
Olesa Vallespí, Roser
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Abstract
CXCR4 is an intermembrane receptor protein of the chemokine type, which is part of the cytokine family, which has a natural ligand called CXCL12/SDF-1.
The chemokine receptor CXCR4 has been shown to be a prognostic marker in several types of cancer and this suggests that deregulation of this protein may contribute to the progression of this disease.
The HIV virus uses the CXCR4 receptor to access the host cell and it has also been shown that CXCL12 / SDF-1 could inhibit HIV infection by steric hindrance of viral gp120 binding to CXCR4, which converts to CXCR4 in an important therapeutic target in the development of an anti-HIV drug.
This work will look at the relationship between CXCR4, HIV and cancer and will synthesize new candidates as an inhibitors of CXCR4 from obtaining pure thi-ophene-2,5-dicarboxaldehyde that will be functionalized with five different amines in order to of forming new structures as potential inhibitors of CXCR4.
Finally, in order to carry out this procedure, the methodologies of Todd C. Sutherland and Albert Gibert will be followed and then the molecules will be analyzed with NMR spectroscopy.
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